Volume : 3, Issue : 11, NOV 2017

ALTERATION IN SERUM LIPID PROFILE PATTERN IN RHEUMATOID ARTHRITIS PATIENTS

SAAD AL-FAWAEIR (PHD), RANIA KHREISAT (MD), BARA'AH ALSHAGGOOR (MD), SAMER ALBOUN (MD), ALA ABU-ALKESHEK (MD)

Abstract

Aim: Rheumatoid Arthritis (RA) is the most common autoimmune arthritis which causes chronic inflammation of the joints and associated with accelerated atherogenesis and increased cardiovascular mortality. Recently it has been focused on the significant association between lipid components and RA disease. This study was designed to investigate the association between lipid components and RA disease Jordanian patients sample.

Methods: The study was conducted at a Rheumatology clinic of royal rehabilitation centre and included 200 RA patients and 50 healthy subjects. Fasting blood samples were drawn for lipid analysis .Relationship between the two group results was assessed using Pearson’s correlation method.

Results: Blood samples were collected from 200 patients attended Rheumatology clinics in royal rehabilitation centre in King Hussein Medical Centre during the period from 15 June 2016 to 27 March 2017, 32 were males (16%)and 168 were female (84%) and also from 50 healthy subjects. Mean duration of disease was 6.75 ± 2.09 years and mean age was 48 ± 9.3 . The results of the patients had shown a high mean serum level of total cholesterol ( TC) in comparison to control group with a significant difference 218.9 ±37.5 Vs 187.6 ± 42.3 (p <0.05).The mean serum level of LDL-C in patients was significant higher than the mean serum level of LDL-C in control group 139.9 ± 21.6 Vs 112.3 ± 19.8 (p <0.05). On the other hand the mean serum TG level in patients was significant higher than the mean serum TG level in control group with significant difference (p >0.05)( 234.6 ±87.3 Vs 177.3 ±35.8), the mean serum level of HDL-C in patients with RA was significant lower than the mean serum level of control group, with a significant difference (p <0.05) (32.8 ±15.6 Vs 47.3 ± 7.5).

Conclusion: RA is a disease with lipid paradox. A high inflammatory burden is associated with low level of HDL-C, high LDL-C and Total cholesterol.

Article : Download PDF

Cite This Article

Article No : 9

Number of Downloads : 839

References

1."Handout on Health: Rheumatoid Arthritis". National
Institute of Arthritis and Musculoskeletal and Skin
Diseases. August 2014. Retrieved July 2, 2015.
2. Majithia V, Geraci SA (2007). "Rheumatoid arthritis:
diagnosis and management". Am. J. Med. 120 (11):
936–
3. Maradit-Kremers H; Crowson CS; Nicola PJ;Ballman
KV.Arthritis Rheum 2005 Feb; 52(2):402-11.
4. Situnayake RD and Kitas G. Dyslipidemia and
rheumatoid arthritis. Ann Rheum Dis 1997; 56:
341-342
5. Park YB, Lee SK, Lee WK, Suh CH, Lee CW, Lee CH,
Song CH and Lee J. Lipid profiles in untreated patients
with rheumatoid arthritis. J Rheumatol 1999; 26:
1701-1704.
6. Choi HK and Seeger JD. Lipid profiles among US
elderly with untreated rheumatoid arthritis- -the Third
National Health and Nutrition Examination S.
7. Avina-Zubieta J., Abrahamowicz M., De Vera M., Choi
H., Sayre E., Rahman M., (2013) Immediate and past
cumulative effects of oral glucocorticoids on the risk of
acute myocardial infarction in rheumatoid arthritis: a
population-based study. Rheumatology (Oxford) 52:
68–75.
8. Aviña-Zubieta J., Choi H., Sadatsafavi M., Etminan M.,
Esdaile J., Lacaille D. (2008) Risk of cardiovascular
mortality in patients with rheumatoid arthritis: a
meta-analysis of observational studies. Arthritis Care &
Research 59: 1690–169
9. Van Halm V., Peters M., Voskuyl A., Boers M., Lems
W., Visser M., (2009) Rheumatoid arthritis versus
diabetes as a risk factor for cardiovascular disease: a
cross-sectional study, the Carré Investigation. Annals of
the Rheumatic Diseases68: 1395–1400
10. Lindhardsen J., Ahlehoff O., Gislason G., Madsen O.,
Olesen J., Torp-Pedersen C., (2011) The risk of
myocardial infarction in rheumatoid arthritis and
diabetes mellitus: a Danish nationwide cohort study.
Ann Rheum Dis 70: 929–934
11. Peters M., Van Halm V., Voskuyl A., Smulders Y.,
Boers M., Lems W., (2009) Does rheumatoid arthritis
equal diabetes mellitus as an independent risk factor
for cardiovascular disease? A Prospective Study.
Arthritis Rheum 61: 1571–1579
12. Kitas G., Banks M., Bacon P. (2001) Cardiac
involvement in rheumatoid disease. Clin Med 1: 18–21
13. Mavrogeni S., Spargias K., Markus sis V., Kolovou G.,
Demerouti E., Papadopoulos E., (2009) Myocardial
inflammation in autoimmune diseases: investigation
by cardiovascular magnetic resonance and
endomyocardial biopsy. Inflame Allergy Drug Targets
8: 390–397.
14. Satlor, M.D.; David W.Mc.Caley, M.D. ”Explaining
How “High-Grade”Systemic Inflammation Accelerates
Vascular Risk in Rheumatoid Arthritis”.Circulation
2003;108:2957-2963.
15. Park YB, Lee SK, Lee WK, Suh CH, Lee CW, Lee CH,
et al. Lipid profiles in untreated patients with
Rheumatoid arthritis. J Rheumatol. 1999;26(8):
1701–1704.
16. Van Leuven SI, Franssen R, Kastelein JJ, Levi M,
Stroes ESG, Tak PP. Systemic inflammation as a risk
factor for atherothrombosis. Rheumatol.
2008;47(1):3–7.
17. Egeland T; Munthe E. The role of the laboratory in
rheumatology. Rheumatoid factors Clin Rheum Dis
1983; 9:135
18. Lazarevic MB, Vitic J, Mladenovic V, Myones BL.
Dyslipoproteinemia in the course of active
rheumatoid arthritis. Semin Arthritis Rheum
1992,22:172-178.
19. Dessein PH, Stanwix AE, Joffe BI. Cardiovascular
risk in rheumatoid arthritis versus osteoarthritis:
acute phase response related decreased insulin
sensitivity and high-density lipoprotein cholesterol
as well as clustering of metabolic syndrome features
in rheumatoid arthritis. Arthritis Res 2002, 4:R5.
20. Hurt-Camejo E, Paredes S, Masana L, Camejo G.
Elevated levels of small, lowdensity lipoprotein with
high affinity for arterial matrix components in patients
with rheumatoid arthritis:possible contribution of
phospholipase A2 to this atherogenic profile. Arthritis
Rheum 2001,44:2761- 2767
21. Svenson KL, Lithell H, Hallgren R, Selinus I,Vessby
B. Serum lipoprotein in active rheumatoid arthritis and
other chronic inflammatory arthritides. I.Relativity to
inflammatory activity. Arch Intern Med 1987,
147:1912-1916.
22. MunroR, MorrisonE, McDonald AG, Hunter JA,
Madhok R, CapellHA. Effect of
disease modifying agents on the lipid profiles of
patients with rheumatoid arthritis. Ann Rheum Dis
1997,56:374-377.
23. Del Rincon ID, Williams K, Stern MP,Freeman GL,
Escalante A High incidence of cardiovascular
events in a rheumatoid arthritis cohort not explained
by cardiac risk factors. Arthritis Rheum 2001,
44:2737-2745.