Volume : 2, Issue : 10, OCT 2016
APPRAISAL OF OXIDATIVE STRESS IN OPEN VERSUS LAPARASCOPIC CHOLECYSTECTOMY
Dr. Amrita Mukherjee, Dr. Soumya Gayen, Dr. Jayanta Kumar Rout
Abstract
Cholecystectomy is one of the most common surgeries in the operative world. The choice between open and laparoscopic procedures is a major point of decision taking among surgeons. This study aims to evaluate the effect of oxidative stress on these procedures and how it influences the course of these procedures. Out of 50 study subjects 25 were operated on by open and 25 by laparoscopic procedures and the total antioxidant (TAS) and thiobarbituric acid reactive substances(TBARS) were assayed preoperatively, 90 mins and 12 hours postoperatively. It was found that the level of TBARS was significantly higher in open cholecystectomy in all three temporal profile and TAS was lower in open cases.
Keywords
Oxidative Stress, Total Antioxidant Status, Thiobarbituric Acid Reacting Substances, Cholecystectomy, Tbars
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Article No : 4
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References
1. Bukan MH, Bukan N, Kaymakcioglu N, Tufan T. Effects of open vs. laparoscopic cholecystectomy on oxidative stress. Tohoku J Exp Med. 2004 Jan;202(1):51-56. 2. Stipancic I, Zarkovic N, Servis D, Sabolovic S, Tatzber F, Busic Z. Oxidative stress markers after laparoscopic and open cholecystectomy. J Laparoendosc Adv Surg Tech A. 2005 Aug;15(4):347-52.
Research Paper E-ISSN NO : 2455-295X | VOLUME : 2 | ISSUE : 10 | OCT 2016
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3. Catherine Rice Evans & Nicholas J. Miller. Estimation of total antioxidant status Assay from serum, Methods in ENZYMOLOGY, Vol 234, Part D, 1994: 279 – 293. 4. Dahle LK,Hill EG,Holman RT.The thiobarbituric acid reaction and the auto oxidationof polyunsaturated fatty acid methyl ester.Arch Biochem Biophys 1962;98:252-261 5. Cruickshank AM, Fraser WD, Burns HJG, Van Damme J, Shenkin A. Response of serum interleukin-6 in patients undergoing elective surgery of varying severity. Clin Sci 1990; 79: 161–165. 6. Reilly PM, Bulkley GB. Tissue injury by free radicals and other toxic oxygen metabolites. Br J Surg 1990; 77: 7. Gal I,Roth E,Lantos J,Verga G & Jaberansari M T 1997,Inflammatory mediators and surgical traume regarding laparoscopic access:free radical mediated reactions.Acta Chir.Hung: 36, 97-99,1324–1325. 8. Glantzounis GK,Tselepsis AD (2001):Laparoscopic surgery induced changes in oxidative stress markers in human plasma:Surg.Endosc.15.1315-1319 9. Schietroma M,Carlei F,(2001):Laparoscopic versus open cholecystectomy.An analysis of clinical and financial aspects.Panminerva Med.43,239-242 10. Evaluation of Oxidative Stress in Laparoscopic Cholecystectomy : Baris Zulfikaroglu, Mahmut Koc, Atilla Soran, Ferruh K. Isman, and Ismail Cinel: Surg Today (2002) 32:869–874 11. Seven R,Seven A,Erbil Y,1999:Lipid peroxidation and antioxidant state after laparoscopic and open cholecystectomy.Eur.J.Surg.165,871-874.
