Volume : 2, Issue : 5, MAY 2016

ER PR EXPRESSION IN NON-GERM CELL OVARIAN CARCINOMA

Dr. Sandhya.V, Dr.Tilagarani K

Abstract

Context: Hyperestrogenia is an important risk factor for ovarian cancer. The detection of ER, PR receptors in ovarian cancer provides further evidence that ovarian carcinoma are hormone dependant and therefore are amenable to hormone therapy. Settings and Design : Cross-sectional study . Aim: The present study thus  aims to study ER, PR expression in non-gem cell  ovarian carcinoma and to correlate it with histopathological and clinical features. Material and methods: 30 consecutive cases of non germ cell ovarian cancer between January 2005 to December 2012 were retrieved from the records of the Pathology Department  at PSGIMS&R. The paraffin-embedded H & E slides of the 30 cases were examined. The clinical details and histological type, grade of the neoplasm were observed. Immunohistochemical staining for ER and PR was done. Results: ER, PR were frequently expressed by serous, endometriod, mucinous carcinoma and granulosa cell tumor. Clear cell, undifferentiated carcinoma and malignant Brenner tumor lacked receptor expression. An increase in PR expression from Grade 1 to Grade 3 epithelial ovarian carcinoma  was noted with a fall in PR expression with increasing stage . A fall in ER expression and a mild increase in PR expression was observed in post menopausal ovarian carcinoma Conclusion: ER, PR expression was frequently seen in serous, endometriod, mucinous carcinoma and granulose cell tumor. The frequency of PR positive epithelial ovarian carcinoma increased with increasing grade of the tumor while the loss of PR expression was associated with a higher stage.

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