Volume : 1, Issue : 2, DEC 2015

EXPLORATION & WONDERS OF MEDICINAL PLANT “ASAFOETIDA”(HEENG) CONSTITUENT GALBANIC ACID AS ANTICANCEROUS AND ANTIMUTAGENIC AGENT

Syeda Sarah Abbas, Safila Naveed, Fatima Qamar, Saba Javed Hussain, Syed Hameez Jawed

Abstract

Asafetida is a oleo-gum resin, it is a dried latex obtained from roots and rhizomes by incision. Asafetida is not only used as a culinary spice but also traditionally used to treat various diseases, including asthma, gastrointestinal disorders and intestinal parasites. This oleo-gum-resin possess antifungal, anti-diabetic, anti-inflammatory, anti-mutagenic and antiviral, antispasmodic, antioxidant, ant diabetic, antimicrobial, antiulcer ,anti hemolytic, chemo preventive. There are various chemical compounds comprises of sugars and polysulfide. Asafetida chiefly subsumes resin (40-65%), gum (20-25%), and volatile oil (4-20%). The asafetida comprises a number of sesquiterpenes of which assaresinotannol is
the chief sesquiterpene. Asafetida is also used as a flavoring agent and used as a constituent of many spice mixtures. It is used to flavor, curries, meatballs, daal and pickles. Asafetida is also used as a flavoring agent and used as a constituent of many spice mixtures. Galbanic acid (GBA) is the active constituent present in the asafetida having anti cancerous activity, it provide inhibitory effects on HIF-1 activation during hypoxia
and normoxia. The investigation of galbanic acid (GBA) has done by fluorescence quenching, absorption spectroscopy, FT-IR, molecular docking and molecular dynamics (MD) simulation procedures.

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