Volume : 4, Issue : 7, JUL 2018

PREOPERATIVE SERUM THYROGLOBULIN IN PREDICTION OF THYROID MALIGNANCY

BEGZADA HASUKI?, AMRA JAKUBOVI?-?I?KUŠI?, BELKISA IZI?, EMIR ŠEHANOVI?, INDIRA MEHMEDAGI?, JASMINA ?UG, ŠEFIK HASUKI?

Abstract

Background: The aim of this study is to determine whether serum thyroglobulin (Tg) values have a predictive role in thyroid cancer in patients with thyroid nodules. Patients and Methods: The prospective study, included 100 patients with scintigraphic cold thyroid nodules divided into two groups. Demographic datas, Tg levels and final histopathological findings were recorded. The first group consisted of 50 patients with histopathological verified malignant nodules and a second group of 50 patients with histopathological verified benign nodules. Tgwere estimated by the radio-immunity assay (RIA) method. Results: Average values of Tg in the groups with benign nodules were 24 (9.8 -98.2) and in the groups with malign nodules were 69.5 (15-277) ng / mL. Tg values were significantly higher in patients with malignant nodules (p=0.03).Tg values were not predictive for thyroid malignancy. Conclusion: Although, we did not found predictive Tg value, we recomend further investigating in combinatin with other clinical parameters (age, sex, tumor size, ultrasonography caracteristics) in patinets with thyroid nodules with indeterminate cytology.

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