Volume : 3, Issue : 1, JAN 2017

STUDY OF SERUM LIPID PROFILE AND LIPID RATIOS IN PATIENTS WITH RENAL FAILURE

SAAD AL-FAWAEIR (PhD), HEBA AL-SHAWABKEH (CHEM. ENG)

Abstract

Background: The burden of kidney disease is increasing rapidly worldwide and has become a major health issue. An association between lipid profile and renal failure has been recently reported in many studies in several countries. Aim: The current study was undertaken to examine the association of serum lipids, lipid ratios with Chronic Renal Failure in Jordan population. Methods: The study was carried out on 75 pre-dialysis chronic kidney disease patients attending out-patient clinic in Prince Zaid Military Hospital in Al-Tafilah in Jordan from February to October 2014 and 50 control subjects, all factors that may lead to dyslipidaemia were excluded in all subjects. Lipid profiles were measured by standard methods. Data were analyzed using a statistical software SPSS version 20.0, p-value <0.05 was considered significant. Results: Subjects with Chronic Renal Failure have significant higher total cholesterol concentrations compared with control group (214.32 ± 75.15 Vs. 177.41 ± 35.37 mg/dL, p< 0.05); also they have significant higher triglyceride concentrations (189.46 ± 68.53 Vs. 147.67 ± 94.35 mg/dL , p< 0.05). The mean ratio of total cholesterol/HDL-cholesterol was significantly higher in the Patients group than healthy subjects (4.53 ± 1.43 Vs. 3.81 ± 1.72, p< 0.05). LDL-cholesterol concentrations were lower in healthy groups (125.14 ± 63.39 Vs. 113.76 ± 35.63 mg/dL, p< 0.05). HDL-cholesterol concentrations were higher in healthy groups (54.14 ± 13.49 Vs. 43.16 ± 15.42 mg/dL, p< 0.05). The LDL-C/HDL-C ratios were higher in patients group (2.14 ± 1.49 Vs.1.16 ±0.92 mg/dL, p< 0.05). Conclusion: Abnormalities in lipids levels are common in pre-dialysis chronic kidney disease patients. It is valuable to investigate and treat dyslipidaemia early in the course of the disease as it may prevent further progression of the renal damage.

Article : Download PDF

Cite This Article

Article No : 15

Number of Downloads : 959

References

1. Cotran, RS S.; Kumar, Vinay; Fausto, Nelson; Robbins, Stanley L.; Abbas, Abul K. Robbins and Catron pathologic basis of disease. St. Louis, MO: Elsevier Saunders.ISBN 0-7216-0187-1(2005). 2. Meyer TW and Hostetter T.H .Uremia N Engl J Med. 2007; 357(13):1316. 3. Moorhead JF; Chan MK; El-Nahas M; et al. Lipid nephrotoxicity in chronic progressive glomerular and tubule intersticial disease. 1982; Lancet 2:1309-11. 4. Massy ZA; Kasiske BL. Post-transplant hyperlipidemia : mechanisms and management. J Am Soc Nephrol 1996; 7: 971-7. 5. Schaeffner ES and Kurth T. Cholesterol and the risk of renal dysfunction in apparently healthy men. 2003 Aug; 14(8):2084-91. 6. Freedman DS and Otvos JD. Relation of lipoprotein subclasses as measured by proton nuclear magnetic resonance spectroscopy to coronary artery disease. 1998 Jul; 18(7):1046-53. 7. Krolewski DS , Warram JH, Christlieb AR. Hypercholesterolmia- a determinant of Renal function loss and deaths in IDDM patients with nephropathy . Kidney Int 45: S 125-31.1994. 8. Kasiske BL. Hyperlipidemia in patients’ chronic renal disease. Am J Kidney 1998; Dis 32: S 142-56. 9. Nolan CR; Anderson RJ: Hospital- acquired acute renal failure. Jam Soc Nephrol 1998; 9:710-8. 10. Eknoyan G. Lameire N, Barsoum R, Eckardt KU. Levin A. et al . The burden of kidney disease: improving global outcomes. Kidney Int 66: 1310-1314 (2004).
11. Attman PO, Samuelsson O. Alaupovic P. Lipoprotein metabolism and renal failure. Am J Kidney Dis 21: 573-592(1993). . 12. Deighan CJ. Caslake MJ. McConnell M. Boulton-Jones JM, Packard CJ. Altherogenic lipoproteins phenotype in end stage renal failure: origin and extent of small dense low-density lipoprotein formation. Am J Kidney Dis 35:852-862 (2000). 13. Brunskill NJ. Albumin signals the coming of age of proteinuric nephropathy. J Am Soc Nephrol 15:504-505, 2004. 14. Sharwan K Y, Niraj N and Dilliram N. Study of serum lipid profile in renal failure patients attending Nobel Medical College. Journal of Nobel Medical College Vol. 2, No.2, Issue 4. 24-28. 15. Sakurai, T .O.k.a . T. Hasegawa, H. Igaki, N. MIiki , S and Goto, T. Comparison of lipids, apoproteins and associated enzyme activities between diabetic and nondiabetic end-stage renal failure renal diseases . Nephron 61:409-14 (1992). 16. Vaziri ND, SatoT, and Liang K. Molecular mechanism of altered cholesterol metabolism in focal glomerulosclersis . Kindey Int 63:1756-1763(2003). 17. McCosh, E. J, Solangi, K, Rivers, J.M and Goodman A. Hypertriglyceridemia in patients with chronic renal insufficiency. Amer. J. Clin. Nutr, 28:1036-1043 (1975). 18. Alwash, S.AM. Physiological study of some hematological and biochemical parameters in patients with diabetic nephropathy. Master thesis, College of Medicine, University of Babylon, Babylon, Iraq (2011). . 19. Kadhum, W.A. Serum lipid profile in renal failure patients. A master thesis, College of medicine , University of Kufa, An Najaf, Iraq (2008).