Volume : 4, Issue : 7, JUL 2018

STUDY OF THE ASSOCIATION BETWEEN SERUM LIPID PROFILE ABNORMALITIES AND HYPOTHYROIDISM

SAAD AL-FAWAEIR (PHD), ALAA ABU-ALKESHEK(MD), AREEN AL-ZGHOUL(MD), ABD-ALRAHMAN AL-HAWARI(BDS), KAFA ALDALALAH (MD)

Abstract

Background/ Objective: Hypothyroidism is a common endocrine problem in which the thyroid gland does not produce enough thyroid hormone. Hypothyroidism results from reduced secretion of total thyroxine (T4) and triiodothyronin (T3). Thyroid hormones have an essential role in mobilization, synthesis and metabolism of lipids. Therefore the current study was designed to examine the contributive role of hypothyroidism in development of dyslipidemia.

Methods and Materials: Thyroid and lipid profile parameters were analyzed in 175 subjects (125 patients with hypothyroidism compared with sex-matched 50 euthyroid controls) with a mean age 47.6 years (ranged 23-58 years). All patients were attending the endocrinology clinics at King Hussein Medical Center during the period from 15 September 2015 to 27 June 2016. Fully automated analyzers were used to measure thyroid and lipid profile parameters. Data were analyzed using a statistical software SPSS version 20.0. The observed differences in values were analyzed for statistical significance using Student's t-test and p-value

Results: It was found that the patients with clinical hypothyroidism have a significant increase in the mean of cholesterol, triglyceride and low density lipoprotein (LDL) (p<0.05). Non significant decrease of high density lipoprotein was observed in hypothyroid patients. Conclusion: the present study supports the proposal said that there is an association between hypothyroidism and serum lipid profile, characterized by an increase in concentrations of total cholesterol, triglyceride and LDL and by decrease of HDL concentrations. However, patients with hypothyroidism should be monitored for deterioration of thyroid function and dyslipidimia at regular interval.

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